In short: yes. According to Unity, HDRP is supported in their render streaming framework.

The PureWeb plugin currently supports Unity engine 2020 and 2021 LTS, which would equate to HRDP version 10.8.1. For more information on the differences , the comparison of Built-In vs HDRP from Unity is a good resource to consult.

What is HRDP (High Definition Render Pipeline)?

Here's an overview from Unity, and a getting started guide. If you're a visual learner, there's also a video from Unity discussing HDRP.

HRDP runs as a scriptable C# package (https://blog.unity.com/technology/srp-overview). For more information about using the HDRP from an different perspective, check out the following article from the Unity Blog.

The High Definition Render Pipeline: Getting Started Guide for Artists | Unity Blog
In this post we will explore authoring a scene to be rendered using Unity’s High Definition Render Pipeline, also known as HDRP. We’ll walk through starting a new HDRP Project, upgrading the Materials of any imported assets, and learn how to use the new parameters within the Material Inspector to c…
Unity Blog

So How Do I Switch to HRDP?

Standard Unity projects need to be converted to HDRP by your game development team. Depending on the needs and complexity of your project, this can be a substantial amount of work. Please feel free to contact us if you are taking on this work and have questions or feedback.